Ask me anything   I'll be your LaLa if you'll be my Love

"People are rivers, always ready to move from one state of being into another. It is not fair, to treat people as if they are finished beings. Everyone is always becoming and unbecoming."
Kathleen Winter, Annabel  (via silentnostalgia)

(Source: splitterherzen, via pyrrhic-victoria)

— 4 days ago with 17477 notes
#kathleen winter  #annabel  #rivers  #river  #people  #life  #quote 
UC San Diego Part of New Effort to Fight Autoimmune Disorders →


Major multi-year partnership will focus first on rheumatoid arthritis and lupus

The Division of Rheumatology, Allergy and Immunology at University of California, San Diego School of Medicine has been named a key site in a national, multi-institution, multi-year $41.6 million program to speed drug discovery, development, diagnostics and therapies for patients with autoimmune disorders, primarily rheumatoid arthritis (RA) and lupus erythematosus, which affect millions of Americans.

“We will be looking to pinpoint the genes, proteins, chemical pathways and networks involved in these diseases at the single cell level,” said Gary S. Firestein, MD, professor, dean and associate vice chancellor of translational medicine. “This approach allows us to make comparisons across many diseases, revealing new insights and aspects of the disease process. We hope to better understand why some RA patients, for example, respond to therapy and others do not – and develop new therapies that target their condition based upon their particular genetic and environmental variables.”

The effort is part of a five-year, $230 million program called Accelerating Medicines Partnership (AMP), a collaboration between the Food and Drug Administration, the National Institutes of Health (NIH), 10 biopharmaceutical companies and several non-profit organizations. It will initially focus upon autoimmune disorders, type 2 diabetes and Alzheimer’s disease, with other diseases and conditions added in the future. The program for RA and lupus is managed through the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

The unusual cross-sector partnership will emphasize finding tell-tale “biomarkers” for these disease areas, which are molecules that can be helpful for diagnosis or selecting treatment. The group also will identify promising drug targets and ways to reduce the time and cost of developing new therapeutics. A critical component of the effort, say officials, is that industry partners, such as Merck and Pfizer, will make AMP data and analyses publicly accessible to the broad biomedical community.

“To date, treatments for RA and lupus have been aimed at decreasing inflammation and pain,” said Stephen I. Katz, MD, PhD, director of NIAMS. “For the first time, we are bringing together multidisciplinary research teams to achieve a broad, systems-level understanding of these diseases, setting the stage for the development of more effective diagnostic and treatment approaches.”

In a consortium with the University of Colorado, the University of Nebraska and Cedars Sinai Medical Center, UC San Diego will be responsible for using the latest genomics and epigenomics research tools to collect and process tissue and blood samples from patients with RA.

RA is primarily an inflammatory disease of the joints, affecting an estimated 1.5 million Americans, or almost 1 percent of the U.S. adult population. While it most often diagnosed in middle age and occurs with increased frequency in older people, it also strikes children and young adults. Symptoms include pain, selling, stiffness and loss of function in joints. RA typically becomes chronic. There are many treatments, but no cure. Research at UC San Diego in RA has contributed to the discovery of several novel therapies that are currently being used. Despite these advances, many patients still have pain and diminished quality of life.

Both RA and lupus belong to a larger group of autoimmune disorders that includes multiple sclerosis, Crohn’s disease, ulcerative colitis, type 1 diabetes and psoriasis. These diseases, say researchers, share common flaws in immune function and regulation, leading to inflammation that destroys tissues and results in reduced quality of life, disability and increased risk of death.

If successful, the researchers said the combined efforts of academia, the NIH and biotechnology companies can change the way research is performed and create multi-disciplinary teams that can be more effective than individual groups.

— 6 days ago with 33 notes


This scene is SO important. Maleficent is with someone she trusts, someone she considers a friend. And then the next thing she knows, she wakes up in pain, bleeding, with her wings burned off. A huge part of her has been destroyed.

Rape is so prominent in our culture that it is in a Disney movie. Maybe not explicitly, but it is very clear what this scene represents and it is so sad.

(Source: bbuchanann, via luminescentsunshine)

— 1 week ago with 192978 notes

These “coffee kiss” sculptures are part of an ongoing series by Chinese artist Johnson Tsang. Started in 2002, the series is named after a local drink called Yuanyang, which is made using a mixture of three parts coffee and seven parts Hong Kong-style milk tea to perfectly represent both Eastern and Western cultures.


These “coffee kiss” sculptures are part of an ongoing series by Chinese artist Johnson Tsang. Started in 2002, the series is named after a local drink called Yuanyang, which is made using a mixture of three parts coffee and seven parts Hong Kong-style milk tea to perfectly represent both Eastern and Western cultures.

(via luminescentsunshine)

— 1 week ago with 24760 notes
"Get excited about the little things. About wearing a new outfit for the first time. About Sunday brunches with your best friends. About the new cute guy in your class. About finding an extra dollar in your pocket. About anything that even remotely makes you happy because as you grow up, passions fade and enthusiasm gets mistaken for foolishness. So don’t let the grey world stop you from shining."
note to self  (via elauxe)

(Source: c0ntemplations, via givingblowjobs)

— 1 week ago with 191351 notes



Click here for more of Jon Stewart’s coverage of the recent House Committee on Science, Space and Technology hearing.

another reason to hate these pile of shits

(via luminescentsunshine)

— 1 week ago with 125764 notes
"Date someone who is interested in you. I don’t mean someone who thinks you’re cute or funny. I mean someone who wants to know every insignificant detail about you. Someone who wants to read every word you write. Someone who wants hear every note of your favourite song, and watch every scene of your favourite movie. Someone wants to find every scar upon your body, and learn where each one came from. Someone who wants to know your favourite brand of toothpaste, and which quotes resonate deep inside your bones when you hear them. There is a difference between attraction and interest. Find the person who wants to learn every aspect of who you are, and hold onto them."
— 1 week ago with 197136 notes


His name’s Ed and he’s the cutest ginger cat ever.

Photos by ©Ed

(via tastefullyoffensive)

— 1 week ago with 21110 notes
#kitty  #kittykat  #kittycat  #kitten  #cute  #awww  #adorbs  #adorable  #cats  #cats rule the world  #Ed 


Sometimes verbal abuse is so bad that you actually start believing what someone says to you. You begin to think you’re stupid, ugly or fat. You agree that nobody else would ever want to be in a relationship with you. Constantly being criticized and told you aren’t good enough causes you to lose confidence and lowers your self esteem. As a result, you may start to blame yourself for your partner’s abusive behavior.

Remember — emotional abuse is never your fault. In fact, your partner may just be trying to control or manipulate you into staying in the relationship.

Does your partner continuously degrade or belittle you? If you think that just because you aren’t being physically abused nothing is wrong, think again.

Emotional abuse can have devastating consequences on both physical and mental health. While emotional or psychological abuse may be difficult to pinpoint, examples abound. 

Here are some characteristics:

• Using economic power to control you

• Threatening to leave

• Making you afraid by using looks, gestures or actions

• Smashing things

• Controlling you through minimizing, denying and blaming

• Making light of the abuse and not taking your concerns about it seriously

• Continually criticizing you, calling you names, shouting at you

• Emotionally degrading you in private, but acting charming in public

• Humiliating you in private or public

• Withholding approval, appreciation or affection as punishment

— 1 week ago with 91 notes